Motif ID: TAL1_TCF{3,4,12}.p2

Z-value: 0.890


Transcription factors associated with TAL1_TCF{3,4,12}.p2:

Gene SymbolEntrez IDGene Name
TAL1 6886 T-cell acute lymphocytic leukemia 1
TCF12 6938 transcription factor 12
TCF3 6929 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
TCF4 6925 transcription factor 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF4chr18_-_51406359-0.721.5e-03Click!
TCF3chr19_-_16012460.514.5e-02Click!
TCF12chr15_+_55298908-0.371.6e-01Click!
TAL1chr1_-_474680290.068.1e-01Click!


Activity profile for motif TAL1_TCF{3,4,12}.p2.

activity profile for motif TAL1_TCF{3,4,12}.p2


Sorted Z-values histogram for motif TAL1_TCF{3,4,12}.p2

Sorted Z-values for motif TAL1_TCF{3,4,12}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TAL1_TCF{3,4,12}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_158008763 1.717 NM_004288
CYTIP
cytohesin 1 interacting protein
chrX_-_154216929 1.712 NM_001289
CLIC2
chloride intracellular channel 2
chr9_-_129707392 1.609 LOC100131355
ST6GALNAC6
hypothetical protein LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr1_-_158948176 1.459 NM_001778
CD48
CD48 molecule
chr19_-_44060729 1.444 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr1_+_32489426 1.411 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr22_+_43451600 1.393 PRR5
proline rich 5 (renal)
chr12_-_101835183 1.098 PAH
phenylalanine hydroxylase
chr1_-_92724181 1.098 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr16_-_29817841 1.037 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr16_+_11966464 0.874 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr12_-_101835026 0.873 PAH
phenylalanine hydroxylase
chr19_+_17499064 0.867 FAM129C
family with sequence similarity 129, member C
chr19_+_40224480 0.835 HPN
hepsin
chr12_-_101835510 0.825 NM_000277
PAH
phenylalanine hydroxylase
chr14_-_93493519 0.821 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr2_-_233586145 0.819 NGEF
neuronal guanine nucleotide exchange factor
chr2_+_108360798 0.807 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr6_-_41811916 0.781 NM_001167827
TFEB
transcription factor EB
chr2_-_233586164 0.743 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr22_+_38652555 0.730 GRAP2
GRB2-related adaptor protein 2
chr1_-_176205672 0.701 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr17_+_38256886 0.701


chr2_+_169367345 0.664 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr16_+_56286212 0.661 NM_032269
CCDC135
coiled-coil domain containing 135
chr10_+_11246934 0.658 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr1_-_149004852 0.657 CTSS
cathepsin S
chr17_-_53761119 0.652 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr16_-_67943157 0.637 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr22_+_34979118 0.632 APOL1
apolipoprotein L, 1
chr16_-_29818334 0.631 SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr1_+_50342168 0.622 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr12_-_46405477 0.586 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr22_+_22907443 0.585 NM_019601
SUSD2
sushi domain containing 2
chr16_+_4546491 0.569 NM_001145011
LOC342346
hypothetical protein LOC342346
chr11_+_5367182 0.543 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr10_-_73518772 0.537 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr22_+_22907417 0.499 SUSD2
sushi domain containing 2
chr12_+_118590039 0.489 NM_006253
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chrX_+_128741562 0.464 NM_018990
SASH3
SAM and SH3 domain containing 3
chr11_+_65164167 0.462 NM_153253
SIPA1
signal-induced proliferation-associated 1
chr10_+_85923473 0.460 NM_207373
C10orf99
chromosome 10 open reading frame 99
chr2_-_65013070 0.451 LOC400958
hypothetical LOC400958
chr6_-_11490487 0.446 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_+_167456230 0.436 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr17_+_38256710 0.430 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr11_+_66979393 0.427 NM_145200
CABP4
calcium binding protein 4
chr11_-_6005546 0.419 NM_001001917
OR56A1
olfactory receptor, family 56, subfamily A, member 1
chr8_+_21967008 0.416 NM_001114137
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr6_-_66473790 0.412 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr22_+_34979062 0.411 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr6_-_33028790 0.402 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr11_-_16454493 0.399 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr3_-_10307408 0.398 NM_001134941
NM_016362
GHRL

ghrelin/obestatin prepropeptide

chrX_-_111809929 0.393 NM_178175
LHFPL1
lipoma HMGIC fusion partner-like 1
chr17_+_53769562 0.386 LOC100506779
hypothetical LOC100506779
chr19_+_18069596 0.382 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr22_+_23309717 0.382 NM_013430
GGT1
gamma-glutamyltransferase 1
chr6_+_126282078 0.381 NCOA7
nuclear receptor coactivator 7
chr22_-_41672990 0.380 NM_007229
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr11_-_66431910 0.377 NM_022172
PC
pyruvate carboxylase
chr9_+_106306275 0.370 NM_001004485
OR13F1
olfactory receptor, family 13, subfamily F, member 1
chr1_-_224143389 0.357 NM_020997
LEFTY1
left-right determination factor 1
chr7_-_36992221 0.347 NM_130442
ELMO1
engulfment and cell motility 1
chr6_-_30188845 0.346 NM_007028
TRIM31
tripartite motif containing 31
chr21_-_33107813 0.344 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr1_+_50344550 0.344 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr2_-_188086612 0.341 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr20_-_39199936 0.339


chr11_-_5212168 0.334 NM_000519
HBD
hemoglobin, delta
chrX_+_46825179 0.332 RGN
regucalcin (senescence marker protein-30)
chr12_+_56114724 0.330 NM_005538
INHBC
inhibin, beta C
chrX_+_128741578 0.322 SASH3
SAM and SH3 domain containing 3
chr1_-_149004879 0.321 CTSS
cathepsin S
chr1_+_205328834 0.316 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr2_+_68445821 0.315 NM_002664
PLEK
pleckstrin
chr8_-_81155564 0.310 NM_001025252
TPD52
tumor protein D52
chr5_-_142764295 0.310 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr7_-_92693716 0.309 NM_001039372
HEPACAM2
HEPACAM family member 2
chr7_+_113853790 0.308 NM_001172767
NM_148899
FOXP2

forkhead box P2

chrX_-_110400406 0.304 NM_014289
CAPN6
calpain 6
chr1_-_169888373 0.300 NM_000261
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr6_-_41811323 0.293 TFEB
transcription factor EB
chr17_-_46479127 0.291 SPAG9
sperm associated antigen 9
chr22_-_34930705 0.288 NM_030643
NM_145660
APOL4

apolipoprotein L, 4

chr11_-_116168316 0.281 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr13_+_107720561 0.279 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr1_+_179164195 0.278


chr12_+_115481568 0.277 NM_001085481
MAP1LC3B2
microtubule-associated protein 1 light chain 3 beta 2
chr10_+_5228756 0.276 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr1_-_203657803 0.275 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr17_-_44641741 0.275 NM_031498
NM_001198755
NM_001198756
GNGT2


guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2


chr13_+_107720475 0.274 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr22_-_34886727 0.274 NM_145640
APOL3
apolipoprotein L, 3
chr13_+_107720206 0.273 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr19_-_14853166 0.272 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chrX_-_46503540 0.270 SLC9A7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr2_-_151854619 0.267 NM_004688
NMI
N-myc (and STAT) interactor
chr14_-_93919305 0.265 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr14_-_93829309 0.262 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr10_-_73518315 0.259 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr17_-_16816113 0.255 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr1_-_111544603 0.249


chr1_+_205329206 0.248 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr17_-_43390108 0.243 NM_024320
PRR15L
proline rich 15-like
chr13_+_107719977 0.240 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr19_-_38052481 0.237 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chr17_-_9863929 0.236 GAS7
growth arrest-specific 7
chr2_-_97775300 0.235 TMEM131
transmembrane protein 131
chr15_+_89248423 0.232 NM_006122
MAN2A2
mannosidase, alpha, class 2A, member 2
chr4_-_185921384 0.232 ACSL1
acyl-CoA synthetase long-chain family member 1
chr5_-_169657395 0.229 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr2_-_96320185 0.228 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr10_+_7785331 0.227 ITIH2
inter-alpha (globulin) inhibitor H2
chr17_+_40594046 0.227 NM_144608
HEXIM2
hexamthylene bis-acetamide inducible 2
chr7_+_94953148 0.224 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr7_+_72883128 0.220 NM_001305
CLDN4
claudin 4
chr2_-_133256097 0.216 NCKAP5
NCK-associated protein 5
chr11_-_56166490 0.216 NM_001002925
OR5AP2
olfactory receptor, family 5, subfamily AP, member 2
chr10_+_7785347 0.213 ITIH2
inter-alpha (globulin) inhibitor H2
chr7_+_150013716 0.211 NM_015660
GIMAP2
GTPase, IMAP family member 2
chr14_-_93512818 0.210 ASB2
ankyrin repeat and SOCS box containing 2
chr18_-_28606839 0.206 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr16_-_70168449 0.205 NM_000353
TAT
tyrosine aminotransferase
chr17_+_44642587 0.202 NM_001135186
NM_016428
ABI3

ABI family, member 3

chr11_-_88436463 0.202 NM_000842
GRM5
glutamate receptor, metabotropic 5
chrX_+_85404626 0.200 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr1_+_246718487 0.200 NM_001004697
OR2T5
olfactory receptor, family 2, subfamily T, member 5
chr7_+_31693155 0.199 NM_001145123
NM_006658
C7orf16

chromosome 7 open reading frame 16

chr19_-_11549484 0.199 ACP5
acid phosphatase 5, tartrate resistant
chr12_+_12656022 0.198 NM_001310
CREBL2
cAMP responsive element binding protein-like 2
chr3_+_123779122 0.197 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr12_-_120725210 0.197 LOC338799
hypothetical LOC338799
chr20_-_42457717 0.194


chr11_+_5610060 0.194 NM_130390
TRIM34
tripartite motif containing 34
chr6_-_29431950 0.193 NM_030876
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr8_+_110443881 0.192 NM_177531
PKHD1L1
polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1
chr9_+_114376709 0.189 KIAA1958
KIAA1958
chr6_-_32268267 0.189 GPSM3
G-protein signaling modulator 3
chr3_+_120982020 0.187 NM_003889
NM_033013
NR1I2

nuclear receptor subfamily 1, group I, member 2

chr1_-_181889070 0.186 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr5_-_131907071 0.186 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr3_-_44527122 0.183 ZNF852
zinc finger protein 852
chr1_+_242283129 0.181 NM_006352
ZNF238
zinc finger protein 238
chr1_+_108904493 0.179 NM_001010883
FAM102B
family with sequence similarity 102, member B
chr16_+_21623784 0.178 NM_170664
OTOA
otoancorin
chr6_+_52159143 0.173 NM_002190
IL17A
interleukin 17A
chr3_-_180467483 0.172 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr1_-_9052207 0.171 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr19_-_11549441 0.168 ACP5
acid phosphatase 5, tartrate resistant
chr4_+_39084936 0.165 KLB
klotho beta
chr1_-_218286476 0.165 EPRS
glutamyl-prolyl-tRNA synthetase
chr1_+_26728846 0.164 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr4_-_116254381 0.164 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr2_+_191009265 0.163 MFSD6
major facilitator superfamily domain containing 6
chrX_-_46503415 0.162 NM_032591
SLC9A7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr7_+_90176647 0.162 NM_012395
CDK14
cyclin-dependent kinase 14
chr1_+_100099353 0.161 NM_000645
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr5_-_134810696 0.161 NM_130848
C5orf20
chromosome 5 open reading frame 20
chr3_-_44527083 0.160 ZNF852
zinc finger protein 852
chr10_+_7785235 0.160 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr1_+_207926172 0.159 NM_181755
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr12_-_8110268 0.156 C3AR1
complement component 3a receptor 1
chr9_+_35663852 0.153 NM_001216
CA9
carbonic anhydrase IX
chr5_+_169749068 0.153


chr17_-_9864048 0.152 GAS7
growth arrest-specific 7
chr12_-_6615348 0.152 NM_020400
LPAR5
lysophosphatidic acid receptor 5
chr1_+_6537924 0.151 NM_138697
NM_177540
TAS1R1

taste receptor, type 1, member 1

chrX_-_110400321 0.150 CAPN6
calpain 6
chr15_+_56511466 0.150 NM_000236
LIPC
lipase, hepatic
chr9_+_95886558 0.148 NM_152422
PTPDC1
protein tyrosine phosphatase domain containing 1
chr19_-_11549508 0.147 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chr9_+_95886625 0.145 PTPDC1
protein tyrosine phosphatase domain containing 1
chr1_-_6343306 0.144 NM_181865
ACOT7
acyl-CoA thioesterase 7
chr6_+_43005126 0.141 CNPY3
canopy 3 homolog (zebrafish)
chr13_-_40491405 0.138 ELF1
E74-like factor 1 (ets domain transcription factor)
chr18_+_41659542 0.137 NM_213602
SIGLEC15
sialic acid binding Ig-like lectin 15
chr18_+_53170718 0.136 NM_015879
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr20_-_44612619 0.136 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr4_+_39084867 0.133 NM_175737
KLB
klotho beta
chr5_-_142764168 0.133 NM_001018076
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr14_+_19513442 0.130 NM_001005486
OR4K15
olfactory receptor, family 4, subfamily K, member 15
chr11_+_5558682 0.130 NM_001005162
OR52B6
olfactory receptor, family 52, subfamily B, member 6
chr19_-_12858956 0.129 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr8_-_20084892 0.122 NM_001135691
NM_001142324
NM_001142325
NM_003053
SLC18A1



solute carrier family 18 (vesicular monoamine), member 1



chr1_+_203204667 0.122 NFASC
neurofascin
chr10_+_80743769 0.122 ZMIZ1
zinc finger, MIZ-type containing 1
chr10_+_7785290 0.122 ITIH2
inter-alpha (globulin) inhibitor H2
chr2_-_25320299 0.122 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr1_-_9052253 0.118 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr3_+_63859114 0.118 NM_001177387
ATXN7
ataxin 7
chr2_+_61258053 0.115 NM_152392
AHSA2
AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)
chr21_+_17841297 0.115 CXADR
coxsackie virus and adenovirus receptor
chr19_-_56537189 0.114 NM_001163922
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr8_-_68821131 0.114 NM_020361
CPA6
carboxypeptidase A6
chr6_+_36318922 0.114 NM_173676
NM_001145716
PNPLA1

patatin-like phospholipase domain containing 1

chr22_+_20880112 0.114


chr19_-_4289750 0.113 NM_001013841
NM_017720
STAP2

signal transducing adaptor family member 2

chr19_+_51190535 0.113 CCDC61
coiled-coil domain containing 61
chr22_+_22445035 0.111 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.84 2.60e-09 GO:0007606 sensory perception of chemical stimulus
3.94 1.02e-08 GO:0007608 sensory perception of smell
2.75 5.30e-07 GO:0007600 sensory perception
2.27 9.92e-07 GO:0050877 neurological system process
1.87 6.75e-04 GO:0003008 system process
1.30 3.44e-02 GO:0050896 response to stimulus
18.11 4.81e-02 GO:0043277 apoptotic cell clearance

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.34 4.64e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.13 6.87e-10 GO:0004984 olfactory receptor activity
2.71 1.38e-07 GO:0004930 G-protein coupled receptor activity
2.03 1.44e-06 GO:0004872 receptor activity
2.21 2.57e-06 GO:0004888 transmembrane receptor activity
1.80 4.91e-05 GO:0004871 signal transducer activity
1.80 4.91e-05 GO:0060089 molecular transducer activity